"garlic" - a great medicine

Dear Friends,
Iam going to tell you the importance of Garlic in our day to day life. Please read the following article for your benefit...

Garlic
Although garlic may not always bring good luck, protect against evil or ward off vampires, it is guaranteed to transform any meal into a bold, aromatic and healthy culinary experience.
Fresh, dried and powdered garlic are available in markets throughout the year, however, fresh varieties from <?xml:namespace prefix = st1 ns = "urn:schemas-microsoft-comffice:smarttags" /><st1:State w:st="on"><st1lace w:st="on">California</st1lace></st1:State> are in season from July through December.
Garlic is arranged in a head, called the "bulb," averaging about 2 inches in height and diameter consisting of numerous small separate cloves. Both the cloves and the entire bulb are encased in paper-like sheathes that can be white, off-white or pinkish. Although garlic cloves have a firm texture, they can be easily cut or crushed. The taste of garlic is like no other - it hits the palate with a hot pungency that is shadowed by a very subtle background sweetness. While elephant garlic has larger cloves, it is more closely related to the leek and therefore does not offer the full health benefits of regular garlic.

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Health Benefits
Whole books have been written about garlic, an herb affectionately called "the stinking rose" in light of its numerous therapeutic benefits. A member of the lily or Allium family, which also includes onions, garlic is rich in a variety of powerful sulfur-containing compounds including thiosulfinates (of which the best known compound is allicin), sulfoxides (among which the best known compound is alliin), and dithiins (in which the most researched compound is ajoene). While these compounds are responsible for garlic's characteristically pungent odor, they are also the source of many of its health-promoting effects. In addition, garlic is an excellent source of manganese, a very good source of vitamin B6 and vitamin C and a good source of selenium.
Cardiovascular Benefits
Numerous studies have demonstrated that regular consumption of garlic lowers blood pressure, and decreases platelet aggregation, serum triglycerides and LDL-cholesterol (the potentially dangerous form) levels while increasing serum HDL-cholesterol (the protective form) and fibrinolysis (the process through which the body breaks up blood clots), and stimulating the production of nitric oxide in the lining of blood vessel walls, which helps them to relax. As a result of these beneficial actions, garlic helps prevent atherosclerosis and diabetic heart disease, and reduces the risk of heart attack or stroke.



A study published in the November 2004 issue of Preventive Medicine shows that garlic also inhibits coronary artery calcification, a process that serves as a marker for plaque formation since the body lays down calcium in areas that have been damaged. In this year-long study, patients given aged garlic extract daily showed an average increase in their calcium score of 7.5%, while those in the placebo group had an average increase in calcium score of 22.2%.
One reason for garlic's beneficial effects may be its ability to lessen the amount of free radicals present in the bloodstream. According to a study published in the September 2004 issue of Life Sciences, a daily dose of 1 ml/kg body weight of garlic extract for six months resulted in a significant reduction in oxidant (free radical) stress in the blood of patients with atherosclerosis.
Since atherosclerotic plaques develop when cholesterol circulating in the bloodstream is damaged or oxidized, garlic's ability to prevent these oxidation reactions may explain some of its beneficial effects in atherosclerotic cardiovascular diseases. A German study published in November 2004 indicates that garlic also greatly reduces plaque deposition and size by preventing the formation of the initial complex that develops into an atherosclerotic plaque. Called "nanoplaque," it is formed when calcium binds to proteoheparan sulfate and then to LDL cholesterol. Garlic prevents the binding of calcium to proteoheparan sulfate, thus decisively inhibiting plaque generation.

Research presented at the 6th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology held by the American Heart Association <st1:date w:st="on" Year="2005" Day="29" Month="4">April 29, 2005</st1:date> in <st1lace w:st="on"><st1:City w:st="on">Washington</st1:City>, <st1:State w:st="on">D.C.</st1:State></st1lace>, suggests that garlic can help prevent and potentially reverse atherosclerotic plaque formation. The laboratory studies, conducted by well-known German scientist Professor Güaut;nter Siegel, M.D., from the University of Medicine in Berlin, Germany, found that powdered garlic (Kwai ® garlic) reduced the formation of nanoplaque (the first building blocks of atherosclerotic plaque) by up to 40% and reduced the size of the nanoplaque that did form by up to 20%.
Dr. Siegel s research shows that garlic acts in a manner similar to HDL ("good") cholesterol, which prevents the build-up of nanoplaques by hindering the docking of LDL ("bad" cholesterol) to its receptor sites in blood vessels or existing plaques.
Both garlic and HDL were able to reduce plaque formation and size within 30 minutes of incubation in these experiments. Existing plaques were dissolved by up to 25% within 15 minutes after the garlic was introduced, indicating a reversal of existing problems related to build-up of arterial plaque. In addition, calcification of the cholesterol docking sites in the arteries was reduced by up to 50% in the presence of the garlic extracts. (Calcium, although a vital mineral for bone formation and other essential physiological processes, is also one of the key factors involved in the formation of plaque.)


New Research More Fully Explains Garlic's Cardiovascular Benefits
Laboratory research by US and Swedish scientists published in the August 2005 Proceedings of the National Academy of Sciences reveals the mechanism behind garlic's cardiovascular benefits.
The compounds in garlic responsible for its pungency also excite a neuron pathway providing cardiovascular benefits.
Garlic's pungency—and that of the other members of the Alliumgenus of plants, such as onions, leeks and chives—results from its organosulphur compounds, allicin and diallyl disulphide (DADS).
Allicin and DADS are structurally similar to allyl isothiocyanate, a compound found in plants such as mustard, which induces pain and inflammation by activating an excitatory ion channel on neurons in the pain pathway called TRPA1. Exciting these TRPA1 pathway neurons also activates capsaicin-sensitive perivascular sensory nerve endings, which induces vasodilation, the relaxation and enlargement of blood vessels, lowering blood pressure and improving blood flow throughout the body. In the current in vitro (laboratory) study, allicin and DADS were also found to activate the TRPA1 channel.
Garlic's numerous beneficial cardiovascular effects are due to not only its sulfur compounds, but its vitamin C, vitamin B6, selenium and manganese:
Garlic is a very good source of vitamin C, the body's primary antioxidant defender in all aqueous (water-solouble) areas, such as the bloodstream, where it protects LDL cholesterol from oxidation. Since it is the oxidized form of LDL cholesterol that initiates damage to blood vessel walls, reducing levels of oxidizing free radicals in the bloodstream can have a profound effect on preventing cardiovascular disease.
Garlic's vitamin B6 helps prevent heart disease via another mechanism: lowering levels of homocysteine. An intermediate product of an important cellular biochemical process called the methylation cycle, homocysteine can directly damage blood vessel walls.
The selenium in garlic not only helps prevent heart disease, but also provides protection against cancer and heavy metal toxicity. A cofactor of glutathione peroxidase (one of the body's most important internally produced antioxidants), selenium also works with vitmain E in a number of vital antioxidant systems. Since vitamin E is one of the body's top defenders in all fat-soluble areas, while vitamin C protects the water-soluble areas, garlic, which contains both nutrients, does a good job of covering all the bases.
Garlic is rich not only in selenium, but also in another trace mineral, manganese, which also functions as a cofactor in a number of other important antioxidant defense enzymes, for example, superoxide dismutase. Studies have found that in adults deficient in manganese, the level of HDL (the "good form" of cholesterol) is decreased.
Anti-Inflammatory, Anti-Bacterial and Anti-Viral Activity
Garlic, like onions, contains compounds that inhibit lipoxygenase and cyclooxygenase, (the enzymes that generate inflammatory prostaglandins and thromboxanes), thus markedly reducing inflammation. These anti-inflammatory compounds along with the vitamin C in garlic, especially fresh garlic, make it useful for helping to protect against severe attacks in some cases of asthma and may also help reduce the pain and inflammation of osteoarthritis and rheumatoid arthritis. In addition, allicin, one of the sulfur-compounds responsible for garlic's characteristic odor, is a powerful antibacterial and antiviral agent that joins forces with vitamin C to help kill harmful microbes. Allicin has been shown to be effective not only against common infections like colds, flu, stomach viruses, and Candida yeast, but also against powerful pathogenic microbes including tuberculosis and botulism.
Although garlic alone appears unable to prevent infection with Helicobacter pylori, the bacterium responsible for most peptic ulcers, frequently eating this richly flavored bulb may keep H. pylori from doing much damage. A study recently conducted at <st1lace w:st="on"><st1laceName w:st="on">Faith</st1laceName> <st1laceType w:st="on">University</st1laceType></st1lace> in <st1lace w:st="on"><st1:City w:st="on">Istanbul</st1:City>, <st1:country-region w:st="on">Turkey</st1:country-region></st1lace>, compared two groups containing 81 healthy individuals each. One group was selected from individuals who regularly ate lots of raw and/or cooked garlic, while the other group was composed of individuals who avoided it. For 19 months, blood samples were regularly collected from both groups and evaluated for the presence of H.pylori. While the incidence of H.pylori was pretty comparable—the bacterium was found in 79% of garlic eaters and 81% of those who avoided garlic—the garlic consuming group had a clear advantage in that antibodies to H.pylori were much lower in their blood compared to those who ate no garlic. (Antibodies are formed when the immune system reacts to anything it considers a potential pathogen, so less antibodies to H.pylori means less of the bacterium was present.) Among those who ate garlic, those who ate both raw and cooked garlic had even lower levels of antibodies than those who ate their garlic only raw or only cooked.

Laboratory studies recently conducted at the University of Munich, Germany, help explain why garlic may be such a potent remedy against the common cold. In these studies, garlic was found to significantly reduce the activity a chemical mediator of inflammation called nuclear transcription factor (NF) kappa-B.
NF kappa-B is itself activated as part of the immune system's inflammatory response to invading organisms and damaged tissue. So, anything that sets off an inflammatory response -e.g. allergenic foods, a cold or other infection, physical trauma, excessive exercise, excessive consumption of foods containing high levels of omega 6 fatty acids (e.g., meat, corn or safflower oil) - can trigger a surge in NF kappa-B, which in turn not only promotes inflammation but sets up ideal conditions for viruses, including HIV, to replicate. In the blood samples tested in these just published German studies, unfertilized garlic caused a 25% drop in NF kappa-B activity, while sulfur-fertilized garlic lowered NF kappa-B activity by a very robust 41%!



Potent, Even Against Drug-Resistant Strains of Bacteria

Results of two recently published studies suggest that garlic is a potent antibiotic, even against strains that have become resistant to many drugs. One study conducted at the University of California Irvine Medical Center and published in the December 2003 issue of Nutrition showed that garlic juice, even when diluted up to 1:128 of the original juice, demonstrates significant antibacterial activity against a spectrum of pathogens including antibiotic-resistant strains such as methicillin- and ciprofloxacin-resistant staphylococci, vancomycin-resistant enterococci, and ciprofloxacin-resistant Pseudomonas aeruginosa. A second study found that garlic was able to inhibit methicillin-resistant Staphylococcus aureus (MSRA) from human patients that was injected into mice.(MSRA is one of the antibiotic resistant bacteria whose incidence has risen dramatically in recent years in hospitals.) Sixteen hours after the mice were infected, garlic extract, diallyl sulphide or diallyl disulphide (two of the active compounds found in garlic), was given orally. Twenty-four hours after they were infected, the mice were sacrificed and examined. Both garlic extract and its compounds were found to have exerted a number of protective actions against MSRA that significantly decreased the infection while also providing antioxidant protection in the blood, liver, kidney and spleen.
Cancer Protection
The organosulfur compound found in garlic called ajoene may also be useful in the treatment of skin cancer. In a study published in the July 2003 Archives of Dermatological Research, researchers applied ajoene topically to the tumors of patients with either nodular or superficial basal cell carcinoma, and in 17 of the 21 patients, the tumors shrunk significantly. Lab tests of the tumors before and after the application of ajoene revealed a significant decrease in Bcl-2, an apoptosis-suppressing protein. (Apoptosis is the self-destruct sequence used by the body to eliminate cancerous cells.)
Other studies have shown that as few as two or more servings of garlic a week may help protect against colon cancer. Substances found in garlic, such as allicin, have been shown to not only protect colon cells from the toxic effects of cancer-causing chemicals, but also to stop the growth of cancer cells once they develop. While more research is needed to confirm, recent animal research has also suggested that garlic may confer protection against the development of stomach cancer through its potential abilty to decrease H.pylori-induced gastritits.
Cooking garlic with meat appears to reduce the production of carcinogenic chemicals that can occur in meat as a result of cooking methods, such as grilling, that expose meat to high temperatures. Research presented July 2005 at the American Association for Cancer Research's Frontiers in Cancer Prevention Research meeting in Baltimore, MD, suggests that the phytochemical responsible for garlic's pungency may help prevent cancer by inhibiting the effects of one such carcinogen called PhIP.
A cancer-causing heterocyclic amine, PhIP is thought to be one reason for the increased incidence of breast cancer among women who eat large quantities of meat because it is rapidly transformed into DNA-damaging compounds.
Diallyl sulphide (DAS), an organosulfur compound that gives garlic its unique flavor, has been shown to inhibit the transformation of PhIP into carcinogens. DAS blocks this transformation by decreasing the production of the liver enzymes (the Phase I enzymes CYP1A1, CYP1A2 and CYP1B1) that transform PhIP into activated DNA-damaging compounds.
In addition, DAS signals the genes responsible for producing two protective antioxidant enzymes, (glutathione-S-transferase (GST) and superoxide dismutase (SOD), which help protect the body against harmful compounds such as those produced from PhIP.
Ronald Thomas and a team of researchers at <st1lace w:st="on"><st1laceName w:st="on">Florida</st1laceName> <st1laceName w:st="on">A&M</st1laceName> <st1laceType w:st="on">University</st1laceType></st1lace> in <st1:City w:st="on"><st1lace w:st="on">Tallahassee</st1lace></st1:City> treated human breast epithelial cells with equal amounts of PhIP and DAS separately, and the two together, for periods ranging from three to 24 hours.
When PhIP was used alone, it caused the production of a cancer-causing enzyme at every time interval, up to 40-fold, while DAS completely inhibited PhIP from becoming carcinogenic.
Thomas and colleagues found that when DAS and PhIP were added to cell cultures, over the next 24 hours, DAS caused a time dependent increase of protective SOD of 3, 25, 29, and 39-fold, and similar results were seen with increased GST production. These findings suggest that making garlic, onion, chives and other allium vegetables, all of which contain DAS, a staple part of your healthy way of eating may help in preventing breast cancer induced by PhIP in well-done meats. And enjoying these DAS-rich foods may help protect the men you love as well: Consumption of allium vegetables has also been associated with a reduced risk of prostate cancer.

Good intakes of vitamin C and selenium, with which fresh garlic is well-endowed, are also associated with a reduced risk of colon cancer, making garlic a smart addition to any colon cancer prevention plan.



Diabetes Mellitus
Garlic may be able to help protect against a number of the most damaging degenerative effects of diabetes—retinopathy disease of the retina), nephropathy (kidney disease) and neuropathy (nervous system disease)—all of which are caused by an imbalance between the free radicals generated when blood sugar levels remain high and the body's protective antioxidant defenses. A study published August 2003 showed that when diabetic rats were exposed to the cancer drug, streptozotocin, which would normally have produced not only a significant rise in blood sugar levels, but an increase in triglycerides, cholesterol, damaged fats, and other markers of increased inflammation, along with a decrease in the antioxidants the body produces to protect itself, that giving the rats garlic oil both lowered the drug's negative effects while boosting protective antioxidant levels. The rats in this study were given 10 mg of garlic oil per kilogram of body weight daily for 15 days. In humans, a comparable dose of garlic oil would be .7 grams per day, an amount that could be easily consumed if using a garlic oil product, but would take real dedication if consuming cloves. Since a typical garlic clove weighs 3 grams and contains 15mg of total fat, which we can treat as basically synonymous with oil, this would translate to about 46 ½ cloves of garlic!



Protection Against Diabetes-Linked Cardiovascular Disease
Cardiovascular disease is a well-known side-effect of diabetes, but garlic may provide some protection, according to a study published December 2003. When diabetic rats were given garlic extract for an 8-week period, the hyperreactivity of their blood vessels to noradrenaline (a vasoconstrictive hormone) and acetylcholine (a compound involved in nerve transmission) was significantly lessened. According to the researchers, their results suggest that garlic may help prevent the development of abnormal vascular contraction seen in diabetics.
Weight Control
The most potent active constituent in garlic, allicin, has been shown to not only lower blood pressure, insulin and triglycerides in rats fed a fructose (sugar)-rich diet, but also to prevent weight gain, according to a study published in the December 2003 issue of the American Journal of Hypertension. In this study, after 5 weeks of being fed a high fructose diet consisting of 21% protein, 5% fat, 60% carbohydrate, 0.49% sodium and 0,49% potassium, male rats had developed high insulin levels, high blood pressure and high triglycerides. The rats were then divided into 3 groups for the remaining 5 weeks of the study: the first group served as a control; the second was given allicin during the final 2 weeks of the study, and the third was given allicin during the initial 3 weeks. Despite the fact that all three groups consumed the same amount of food, weight rose in the control group and in groups 2 and 3 when not receiving allicin, but remained stable or declined slightly when allicin was given. The researchers concluded that allicin may be of practical value for weight control.



Increased Antioxidant Protection

A study published in the November 2003 E-version of the journal Carcinogenesis showed that levels of a critically important internally produced antioxidant enzyme, glutathione-S-transferase, rose substantially in the stomach and small intestine, and to a lesser extent in the liver and colon, in rats that were put on a short-term feeding regimen that featured two compounds from garlic, diallyl disulfide and diallylthiosulfinate (allicin). Researchers discovered that these garlic compounds selectively induced two genes to produce more of the messenger RNAs (mRNAs) that encode glutathione-S-transferase, and the greatest increases were noted in mRNAs that are normally present only at low levels. The bottom line: eating more garlic may help increase your body's production of this vitally important antioxidant enzyme.


Protection against Asbestos
Asbestos, a well known carcinogen, is thought to cause cell mutations by generating reactive oxygen species (free radicals) and depleting one of the body's most important internally produced antioxidants, glutathione. Garlic contains numerous sulfur compounds and glutathione precursors that act as antioxidants and also demonstrate anti-carcinogenic properties. In a laboratory study published in the November 2004 issue of Toxicology Letters, garlic extract, when administered along with asbestos, so significantly reduced DNA mutations in human blood lymphocytes (a type of immune cell), that the researchers concluded: "garlic extract may be an efficient, physiologically tolerable quencher of asbestos-induced genotoxcity."